TCGA Bladder Cancer Study Reveals Potential Drug Targets, Similarities ...
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a …
The Cancer Genome Atlas - Urothelial Bladder Carcinoma …
16/05/2014 · Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease. They also discovered that, at the molecular level, some subtypes of bladder cancer - also known as urothelial carcinoma - ...
Comprehensive Molecular Characterization Of Muscle …
The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets. Bladder cancer (BC) is one of the most common neoplastic diseases worldwide. With the highest recurrence rate among all cancers, treatment of BC only improved a little in the last 30 years.
TCGA Bladder Cancer Study Reveals Potential Drug Targets, …
Description. This dataset contains summary data visualizations and clinical data from a broad sampling of over 400 bladder urothelial carcinomas. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset.
The Identification Of New Biomarkers For Bladder Cancer: A …
13/05/2020 · However, the role of PTPN6 in bladder cancer (BC) remains unclear. The purpose of this study was to explore the prognostic value of PTPN6 in BC. RNA-seq data from The Cancer Genome Atlas (TCGA) was used to identify the expression level of PTPN6 in BC.
Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas): Bladder ...
29/01/2014 · NCI Press Office. 240-760-6600. Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified new potential therapeutic targets for a major form of bladder cancer, including important genes and pathways that are disrupted in the disease. They also discovered that, at the molecular level, some subtypes of bladder cancer – also ...
The Analysis Of PTPN6 For Bladder Cancer: An Exploratory …
We used the complete The Cancer Genome Atlas (TCGA) RNA-seq dataset and three different published classifiers developed by our groups to assign TCGA’s bladder cancers to molecular subtypes, and examined the prevalence of the most common DNA alterations within them (Supplementary material). We interpreted the results against the background of what was …
TCGA Bladder Cancer Study Reveals Potential Drug Targets …
29/01/2014 · This study of 131 high-grade muscle-invasive urothelial bladder carcinomas, part of The Cancer Genome Atlas (TCGA) project, reports recurrent mutations in 32 genes, including those involved in ...